Clonidine in Opiate Detoxification
نویسندگان
چکیده
Detoxification, the initial step in the treatment of opiate dependence (Freedman, 1980) has been facing difficulties in our country as the widely used drug methadone is not available. Earlier practices were either abrupt withdrawal or gradual tapering of the dose of the opiate to which the individual was dependent. Recently clonidine has been used with success for detoxification and treatment of opiate withdrawal symptoms (Gold et al., 1978; Washton and Resnick,. 1980; Channabasavanna and Subramanya, 1981). Glonidine acts through inhibiting the norepinephrinergic system by a presynaptic feedback mechanism (Hamburg and Fallman, 1981). Studies comparing the efficacy of clonidine with other methods of opiate detoxification are rather few (Washton and Resnick, 1980). The present study was conducted to compare the efficacy of a clonidine with the earlier methods of detoxification, namely abrupt withdrawal and gradual tapering.
منابع مشابه
18 Clonidine and Lofexidine: New Nonopiate Treatments for Opiate Withdrawal
INTRODUCTION Recent studies (Gold et al, 1978; Washton et al, 1980a) showing that the non-opiate antihypertensive agent, clonidine hydrochloride, suppresses signs and symptoms of opiate withdrawal, have suggested that clonidine and similar drugs might be useful in the clinical management of opiate detoxification. The fact that clonidine is not an opiate drug and does not itself produce addictio...
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